The Savvygen™ GI Adenovirus test allows the qualitative detection of Adenovirus by real time PCR in human feces. The product is intended for use in the diagnosis of Adenovirus gastrointestinal infections alongside clinical data of the patient and other laboratory tests outcomes.

Human adenoviruses (HAdV) are ubiquitous DNA viruses that cause a wide spectrum of illness. Adenoviruses are classified in the genus Mastadenovirus, which contains 7 known HAdV species (HAdV-A to HAdV-G). Historically, HAdVs have been classified by hemagglutination and serum neutralization reactions into 51 serotypes, although new adenovirus types identified by genomic data expand the types for a total of 57. They are transmitted by the fecal-oral route and the respiratory route and are associated with acute respiratory disease (accounting for 10% of febrile respiratory diseases in children) and gastroenteritis.  The enteric serotypes most frequently associated with the last symptom are 40 and 41, but additional serotypes 31, 12, 18, 1, 2, 5 and 6 have also been involved in the etiology of acute diarrhea. Diagnosis of Adenovirus infections is currently based on virus isolation in cell culture or antigen detection. However, the need for rapid and sensitive detection methods has led to PCR being the best established among all other methods. The Real time PCR reaction targeting hexon gene is now a method of choice due to its sensibility and specificity

The Savvygen™ GI- Adenovirus test is a ready-to use test which contains in each well all the necessary reagents for real time PCR assay in a stabilized format. In addition, an internal control allows the detection of a possible reaction inhibition. The amplification of the target sequence is detected through the FAM channel whereas the internal control (IC) in HEX channel.